Endocrine Abstracts

Introduction: The prolactinoma is the most common functioning pituitary tumour. There are few long-term studies on the optimal duration of treatment with dopamine agonists prolactinoma to ensure healing without recurrence after stopping the medication and do not provide a consensus on it or on withdrawal criteria treatment.Objectives: To establish the prevalence of withdrawal of treatment macroprolactinomas and evaluate criteria prolactinoma cure medical...

IntroductionMenopausal transition is associated with an increase in the cardiovascular risk, possibly related with the sharp decrease of estrogen levels. Menopausal symptoms and more specifically hot flushes have been previously linked with an increase in cardiovascular risk. On the other hand, non-alcoholic fatty liver disease is considered as another presentation of the metabolic syndrome, conferring additional cardiovascular risk to the affected indiv...

Sex hormone-binding globulin (SHBG) is a circulating plasma glycoprotein produced by the liver, which in the blood binds estrogens and androgens with high affinity and regulates its bioavailability. Low plasma SHBG levels are associated with obesity, metabolic syndrome and non-alcoholic fatty liver disease. Importantly, epidemiological studies have demonstrated that low plasma SHBG levels is a risk factor for developing type 2 diabetes and cardiovascular disease. In the last y...

Adamantinomatous craniopharyngiomas (ACPs) are among the most common intracranial tumours in children and they originate from undifferentiated pituitary progenitors. Mutations in the gene encoding for β-catenin (CTNNB1), which lead to the constitutive activation of the Wnt/β-catenin signalling pathway, have been associated with ACP. These tumours can invade adjacent structures, such as the hypothalamus, which makes comp...

Adamantinomatous craniopharyngiomas (ACPs) are among the most common intracranial tumours in children and they originate from undifferentiated pituitary progenitors. Mutations in the gene encoding for β-catenin (CTNNB1), which lead to the constitutive activation of the Wnt/β-catenin signalling pathway, have been associated with ACP. These tumours can invade adjacent structures, such as the hypothalamus, which makes comp...

Introduction: Fine-needle biopsy with cytologic evaluation remains the diagnostic test of choice to distinguish benign from malignant thyroid nodules, but fails to classify thyroid nodules in 15% to 30% of cases (indeterminate thyroid nodules-ITN). ‘Rule out’ molecular testing improves the diagnostic accuracy, with high sensitivity and negative predictive value, ranging from 86 to 96%. However, these tests are not widely available, and notably increase costs. <p ...

Introduction: 177Lu-Oxodotreotide(PRRT-Lu) has the approval by EMA and FDA since 2017 for the treatment of patients with gastro-entero-pancreatic neuroendocrine tumors(GEP-NET). However, in daily clinical practice it has also been used in other NET tumors such as paragangliomas, lung NET, medullary thyroid cancer, and others. The aim of this study is to describe the characteristics and follow-up of patients treated with PRRT-Lu in a third level hospital in Spain fro...

Introduction: Patients referred for adrenal incidentalomas (AI) are increasing. Current guidelines are controversial on diagnosis and length of follow-up.Objectives: Analyze clinical, radiologic and hormonal characteristics of patients with AI. Evaluate the number and usefulness of tests needed for diagnosis, clinical outcome and follow up.Material and methods: Observational, retrospective study in patients with AI in our endocrino...

Introduction: Hyperthecosis ovarian is a type of hyperandrogenism and severe insulin resistance, usually found in postmenopausal women.Case Report: This case is about a 12 year-old girl who came to our hospital because of a rapidly progressive virilization. She had no medical history. For the previous 10 months, she had felt progressive growth of terminal hair in androgen-dependent areas, abundant hair loss, facial acne and voice changes. Axilarche and p...

GH and IGF1 play an important role in cardiac development and function. Conditions leading to abnormal GH levels are associated with cardiovascular disease. Although acromegaly is associated with hypertension, insulin resistance, diabetes type 2 and dislipemia, several studies ascribe the heart alterations displayed by these patients to the direct action of chronically elevated GH and IGF1 levels.Given that insulin acts as a growth factor to the heart an...